Prognostic Impact of Novel Molecular Subtypes of Small Intestinal Neuroendocrine Tumor.

doi:10.1158/1078-0432.CCR-15-0373

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Article

Prognostic Impact of Novel Molecular Subtypes of Small Intestinal Neuroendocrine Tumor.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jan 2016

Karpathakis Anna, Dibra Harpreet, Pipinikas Chistodoulos, Feber Andrew, Morris Tiffany, Francis Joshua, Oukrif Dahmane, Mandair Dalvinder, Pericleous Marinos, Mohmaduvesh Mullan, Serra Stefano, Ogunbiyi Olagunju, Novelli Marco, Luong TuVinh, Asa Sylvia L, Kulke Matthew, Toumpanakis Christos, Meyer Tim, Caplin Martyn, Meyerson Matthew, Beck Stephan, Thirlwell Christina

Abstract excerpt

PURPOSE: Small intestinal neuroendocrine tumors (SINET) are the commonest malignancy of the small intestine; however, underlying pathogenic mechanisms remain poorly characterized. Whole-genome and -exome sequencing has demonstrated that SINETs are mutationally quiet, with the most frequent known mutation in the cyclin-dependent kinase inhibitor 1B gene (CDKN1B) occurring in only ∼8% of tumors, suggesting that...

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Identifiers

PMID: 26169971
DOI: 10.1158/1078-0432.CCR-15-0373

Genes

CDX1
CELSR3
FBP1
GIPR

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Source receipt: pubmed, retrieved 7 Sept 2026.

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