Article

Diversity of Aβ aggregates produced in a gut-based <i>Drosophila</i> model of Alzheimer’s disease

2024-11-20

Abstract excerpt

Alzheimer’s disease (AD) is a neurodegenerative disease manifested by memory loss and premature death. One major histopathological hallmark of AD is the amyloid plaques formed by aggregates of the amyloid-beta (Abeta) peptide and the Abeta aggregation process results in amyloid fibrils with different structures. Herein, we investigate the heterogeneity of Abeta aggregates produced by Drosophila melanogaster expres...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a0bbf3d4-f0ec-5c9f-9920-653d44aeef0a
DOI: 10.1101/2024.11.19.624423

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Diversity of Aβ aggregates produced in a gut-based <i>Drosophila</i> model of Alzheimer’s diseaseDOI 10.1101/2024.11.19.624423Read

Abeta42 mutants with different aggregation profiles induce distinct pathologies in Drosophila.Semantic proximity Read

Systematic Aβ Analysis in Drosophila Reveals High Toxicity for the 1-42, 3-42 and 11-42 Peptides, and Emphasizes N- and C-Terminal Residues.Semantic proximity Read

Behavioural effects and RNA-seq analysis of Aβ42 mediated toxicity in a Drosophila Alzheimer’s disease modelSemantic proximity Read

pGluAβ increases accumulation of Aβ in vivo and exacerbates its toxicitySemantic proximity Read

Ageing Increases Vulnerability to Aβ42 Toxicity in DrosophilaSemantic proximity Read

Aβ43 is neurotoxic and primes aggregation of Aβ40 in vivoSemantic proximity Read

Expression in Drosophila of Tandem Amyloid β Peptides Provides Insights into Links between Aggregation and NeurotoxicitySemantic proximity Read

Dissecting the pathological effects of human Aβ40 and Aβ42 in <i>Drosophila</i> : A potential model for Alzheimer's diseaseSemantic proximity Read

Aß40 displays amyloidogenic properties in the non-transgenic mouse brain but does not exacerbate Aß42 toxicity in Drosophila.Semantic proximity Read

Efficient imaging of amyloid deposits in Drosophila models of human amyloidoses.Semantic proximity Read

Drosophila Models of Alzheimer's Amyloidosis: The Challenge of Dissecting the Complex Mechanisms of Toxicity of Amyloid-β 42Semantic proximity Read

Curcumin promotes A-beta fibrillation and reduces neurotoxicity in transgenic Drosophila.Semantic proximity Read