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Article

Ageing Increases Vulnerability to Aβ42 Toxicity in Drosophila

12 Jul 2012

Abstract excerpt

Age is the major risk factor for many neurodegenerative diseases, including Alzheimer's Disease (AD), for reasons that are not clear. The association could indicate that the duration or degree of exposure to toxic proteins is important for pathology, or that age itself increases susceptibility to protein toxicity. Using an inducible Drosophila model of AD, we investigated these possibilities by varying the...

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PMID: 22808195
DOI: 10.1371/journal.pone.0040569

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