Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Dissecting the pathological effects of human Aβ40 and Aβ42 in <i>Drosophila</i> : A potential model for Alzheimer's disease

6 Apr 2004

Abstract excerpt

Accumulation of amyloid-beta (Abeta) peptides in the brain has been suggested to be the primary event in sequential progression of Alzheimer's disease (AD). Here, we use Drosophila to examine whether expression of either the human Abeta40 or Abeta42 peptide in the Drosophila brain can induce pathological phenotypes resembling AD. The expression of Abeta42 led to the formation of diffused amyloid deposits,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer's disease research and treatments
Share to Cholinesterase and Neurodegenerative Diseases
Share to Computational Drug Discovery Methods

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 15069204
DOI: 10.1073/pnas.0400895101

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Dissecting the pathological effects of human Aβ40 and Aβ42 in <i>Drosophila</i> : A potential model for Alzheimer's diseasePMID 15069204Read ↗

Drosophila Models of Alzheimer's Amyloidosis: The Challenge of Dissecting the Complex Mechanisms of Toxicity of Amyloid-β 42Semantic proximity Read ↗

Insights from Drosophila melanogaster model of Alzheimer s diseaseSemantic proximity Read ↗

Genetic Dissection of Alzheimer’s Disease Using Drosophila ModelsSemantic proximity Read ↗

Drosophila melanogaster: Deciphering Alzheimer's DiseaseSemantic proximity Read ↗

Systematic Aβ Analysis in Drosophila Reveals High Toxicity for the 1-42, 3-42 and 11-42 Peptides, and Emphasizes N- and C-Terminal Residues.Semantic proximity Read ↗

Abeta42 mutants with different aggregation profiles induce distinct pathologies in Drosophila.Semantic proximity Read ↗

A model for studying Alzheimer's Abeta42-induced toxicity in Drosophila melanogaster.Semantic proximity Read ↗

Behavioural effects and RNA-seq analysis of Aβ42 mediated toxicity in a Drosophila Alzheimer’s disease modelSemantic proximity Read ↗

Transgenic Drosophila models of Alzheimer's disease and tauopathies.Semantic proximity Read ↗

Characterization of a Drosophila Alzheimer's disease model: pharmacological rescue of cognitive defects.Semantic proximity Read ↗

Intraneuronal Aβ, non-amyloid aggregates and neurodegeneration in a Drosophila model of Alzheimer’s diseaseSemantic proximity Read ↗

Expression in Drosophila of Tandem Amyloid β Peptides Provides Insights into Links between Aggregation and NeurotoxicitySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.