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Article

Aβ43 is neurotoxic and primes aggregation of Aβ40 in vivo

10 Apr 2015

Abstract excerpt

The involvement of Amyloid-β (Aβ) in the pathogenesis of Alzheimer's disease (AD) is well established. However, it is becoming clear that the amyloid load in AD brains consists of a heterogeneous mixture of Aβ peptides, implying that a thorough understanding of their respective role and toxicity is crucial for the development of efficient treatments. Besides the well-studied Aβ40 and Aβ42 species, recent data...

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PMID: 25862636
DOI: 10.1007/s00401-015-1419-y

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