pGluAβ increases accumulation of Aβ in vivo and exacerbates its toxicity

Abstract excerpt

Several species of β-amyloid peptides (Aβ) exist as a result of differential cleavage from amyloid precursor protein (APP) to yield various C-terminal Aβ peptides. Several N-terminal modified Aβ peptides have also been identified in Alzheimer’s disease (AD) brains, the most common of which is pyroglutamate-modified Aβ (Aβ pE3-42 ). Aβ pE3-42 peptide has an increased propensity to aggregate, appears to accumulate...

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