Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Curcumin promotes A-beta fibrillation and reduces neurotoxicity in transgenic Drosophila.

PloS one - 1 Jan 2012

Caesar Ina, Jonson Maria, Nilsson K Peter R, Thor Stefan, Hammarström Per

Abstract excerpt

The pathology of Alzheimer's disease (AD) is characterized by the presence of extracellular deposits of misfolded and aggregated amyloid-β (Aβ) peptide and intraneuronal accumulation of tangles comprised of hyperphosphorylated Tau protein. For several years, the natural compound curcumin has been proposed to be a candidate for enhanced clearance of toxic Aβ amyloid. In this study we have studied the potency of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Drosophila
Share to Alzheimer Disease
Share to Amyloid beta-Peptides

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Animals, Genetically Modified

Share to Curcumin

Share to Neurotoxicity Syndromes

Share to Polymerization

Share to Survival Rate

Source

Open in PubMed Open full text

Identifiers

PMID: 22348084
DOI: 10.1371/journal.pone.0031424
PMCID: PMC3278449

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Curcumin promotes A-beta fibrillation and reduces neurotoxicity in transgenic Drosophila.PMID 22348084Read ↗

Diversity of Aβ aggregates produced in a gut-based <i>Drosophila</i> model of Alzheimer’s diseaseSemantic proximity Read ↗

Efficient imaging of amyloid deposits in Drosophila models of human amyloidoses.Semantic proximity Read ↗

Testing the Therapeutic Potential of Doxycycline in a Drosophila melanogaster Model of Alzheimer DiseaseSemantic proximity Read ↗

Inhibition of Abeta Proteotoxicity by Paeoniflorin in Caenorhabditis elegans Through Regulation of Oxidative and Heat Shock Stress ResponsesSemantic proximity Read ↗

Complete phenotypic recovery of an Alzheimer's disease model by a quinone-tryptophan hybrid aggregation inhibitor.Semantic proximity Read ↗

In vivo Evaluation of a Newly Synthesized Acetylcholinesterase Inhibitor in a Transgenic Drosophila Model of Alzheimer’s DiseaseSemantic proximity Read ↗

Impact of nano-conjugate on Drosophila for early diagnosis of Alzheimer’s diseaseSemantic proximity Read ↗

Curcumin inhibits aggregation of alpha-synuclein.Semantic proximity Read ↗

Probing the anti-Aβ42 aggregation and protective effects of prenylated xanthone against Aβ42-induced toxicity in transgenic Caenorhabditis elegans modelSemantic proximity Read ↗

In Vivo Aggregation of β‐Amyloid Peptide VariantsSemantic proximity Read ↗

Expression in Drosophila of Tandem Amyloid β Peptides Provides Insights into Links between Aggregation and NeurotoxicitySemantic proximity Read ↗

Photo-excited Toluidine Blue Inhibits Full-Length Tau Aggregation in Alzheimer’ DiseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.