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Article

Abeta42 mutants with different aggregation profiles induce distinct pathologies in Drosophila.

PloS one - 27 Feb 2008

Iijima Koichi, Chiang Hsueh-Cheng, Hearn Stephen A, Hakker Inessa, Gatt Anthony, Shenton Christopher, Granger Linda, Leung Amy, Iijima-Ando Kanae, Zhong Yi

Abstract excerpt

Aggregation of the amyloid-beta-42 (Abeta42) peptide in the brain parenchyma is a pathological hallmark of Alzheimer's disease (AD), and the prevention of Abeta aggregation has been proposed as a therapeutic intervention in AD. However, recent reports indicate that Abeta can form several different prefibrillar and fibrillar aggregates and that each aggregate may confer different pathogenic effects, suggesting...

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PMID: 18301778
DOI: 10.1371/journal.pone.0001703
PMCID: PMC2250771

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