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Article

Widespread Impact of Natural Genetic Variations in CRISPR-Cas9 Outcomes.

The CRISPR journal - 1 Oct 2024

Li Victoria R, Wu Tinghui, Tadych Alicja, Wong Aaron, Zhang Zijun

Abstract excerpt

The clustered regularly interspaced short palindromic repeats (CRISPR)-CRISPR-associated protein 9 (Cas9) is a genome editing tool widely used in biological research and clinical therapeutics. Natural human genetic variations, through altering the sequence context of CRISPR-Cas9 target regions, can significantly affect its DNA repair outcomes and ultimately lead to different editing efficiencies. However, these...

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Identifiers

PMID: 39436278
DOI: 10.1089/crispr.2024.0020

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