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Decoding myofibroblast origins in human kidney fibrosis

11 Nov 2020

Abstract excerpt

Kidney fibrosis is the hallmark of chronic kidney disease progression; however, at present no antifibrotic therapies exist1–3. The origin, functional heterogeneity and regulation of scar-forming cells that occur during human kidney fibrosis remain poorly understood1,2,4. Here, using single-cell RNA sequencing, we profiled the transcriptomes of cells from the proximal and non-proximal tubules of healthy and...

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PMID: 33176333
DOI: 10.1038/s41586-020-2941-1

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