Article

Brain aging is faithfully modelled in organotypic brain slices and accelerated by prions

2022-02-06

Abstract excerpt

Mammalian models are essential for brain aging research. However, the long lifespan and limited amenability to genetic and pharmacological perturbations have hindered the use of mammals for dissecting aging-regulatory molecular networks and discovering new anti-aging interventions. To circumvent these limitations, we developed an ex vivo model system that faithfully mimics the aging process of the mammalian brain...

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Literature Corpus work: a0951f12-7614-5291-9a90-4e364f2ad30f
DOI: 10.1101/2022.02.06.479288

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