Development of an organotypic brain slice culture model using tissues collected from geriatric mice

Abstract excerpt

Ex vivo organ slice cultures are attractive models to address specific biomedical research questions because they retain complex and dynamic three dimensional architecture. In addition, they require only a few animals as tissue donors thus greatly decreasing the number needed for live animal studies. The model has been most successful using tissues from very young mice, but has generally not been considered for ag...

Topics

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• Alzheimer's disease research and treatments
• Computational Drug Discovery Methods
• Glial Fibrillary Acidic Protein
• Medicinal Plants and Neuroprotection
• Microglia
• Nerve Growth Factors
• Neurofibrillary Tangles
• Organ Culture Techniques

Identifiers and source

Literature Corpus work

3239d496-f3c3-5ed5-beac-bf810bf87fbd

DOI

10.64898/2025.12.23.696302