Article

Dis3L2 regulates cellular proliferation through a PI3-Kinase dependent signalling pathway

2019-10-16

Abstract excerpt

Dis3L2 is a highly conserved 3’-5’ exoribonuclease which is mutated in the human overgrowth disorders Perlman syndrome and Wilms’ tumour. Here, we have generated a new dis3L 2 null mutant and a UAS-nuclease-dead line in Drosophila to demonstrate that the catalytic activity of Dis3L2 is required to control proliferation in imaginal discs. Using RNA-seq on dis3L2 mutant wing discs, we show that the imaginal disc...

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Literature Corpus work: a08d8026-21c6-5a1b-a52b-9d9c6af2cd3d
DOI: 10.1101/806109

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