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Article

The uncoupled chloride conductance of a bacterial glutamate transporter homolog.

Nature structural & molecular biology - 1 May 2007

Ryan Renae M, Mindell Joseph A

Abstract excerpt

Glutamate transporters (EAATs) are pivotal in mammalian synaptic transmission, tightly regulating synaptic levels of this excitatory neurotransmitter. In addition to coupled glutamate transport, the EAATs also show an uncoupled Cl(-) conductance, whose physiological importance has recently been demonstrated. Little is yet known about the molecular mechanism of chloride permeation. Here we show that Glt(Ph), a...

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PMID: 17435767
DOI: 10.1038/nsmb1230

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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