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Article

Glutamate transporters have a chloride channel with two hydrophobic gates.

Nature - 1 Mar 2021

Chen Ichia, Pant Shashank, Wu Qianyi, Cater Rosemary J, Sobti Meghna, Vandenberg Robert J, Stewart Alastair G, Tajkhorshid Emad, Font Josep, Ryan Renae M

Abstract excerpt

Glutamate is the most abundant excitatory neurotransmitter in the central nervous system, and its precise control is vital to maintain normal brain function and to prevent excitotoxicity1. The removal of extracellular glutamate is achieved by plasma-membrane-bound transporters, which couple glutamate transport to sodium, potassium and pH gradients using an elevator mechanism2-5. Glutamate transporters also...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 33597752
DOI: 10.1038/s41586-021-03240-9
PMCID: PMC7954978

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