Article

Expanding the substrate selectivity of the fimsbactin biosynthetic adenylation domain, FbsH

2024-07-26

Abstract excerpt

Nonribosomal peptide synthetases (NRPSs) produce diverse natural products including siderophores, chelating agents that many pathogenic bacteria produce to survive in low iron conditions. Engineering NRPSs to produce diverse siderophore analogs could lead to the generation of novel antibiotics and imaging agents that take advantage of this unique iron uptake system in bacteria. The highly pathogenic and antibiotic...

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Literature Corpus work: a0760f06-1037-5490-91ae-e1e8dd760090
DOI: 10.1101/2024.07.26.605314

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