Article

Global analysis of adenylate-forming enzymes reveals β-lactone biosynthesis pathway in pathogenic <i>Nocardia</i>

2019-11-29

Abstract excerpt

<h4>ABSTRACT</h4> Enzymes that cleave ATP to activate carboxylic acids play essential roles in primary and secondary metabolism in all domains of life. Class I adenylate-forming enzymes share a conserved structural fold but act on a wide range of substrates to catalyze reactions involved in bioluminescence, nonribosomal peptide biosynthesis, fatty acid activation, and β-lactone formation. Despite their metabolic...

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Literature Corpus work: b3c5074a-c9e3-58b7-b261-909555a3e737
DOI: 10.1101/856955

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