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Article

Structures of a non-ribosomal peptide synthetase condensation domain suggest the basis of substrate selectivity.

Nature communications - 4 May 2021

Izoré Thierry, Candace Ho Y T, Kaczmarski Joe A, Gavriilidou Athina, Chow Ka Ho, Steer David L, Goode Robert J A, Schittenhelm Ralf B, Tailhades Julien, Tosin Manuela, Challis Gregory L, Krenske Elizabeth H, Ziemert Nadine, Jackson Colin J, Cryle Max J

Abstract excerpt

Non-ribosomal peptide synthetases are important enzymes for the assembly of complex peptide natural products. Within these multi-modular assembly lines, condensation domains perform the central function of chain assembly, typically by forming a peptide bond between two peptidyl carrier protein (PCP)-bound substrates. In this work, we report structural snapshots of a condensation domain in complex with an...

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PMID: 33947858
DOI: 10.1038/s41467-021-22623-0
PMCID: PMC8097023

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