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Precise Probing of Residue Roles by NRPS Code Swapping: Mutation, Enzymatic Characterization, Modeling, and Substrate Promiscuity of Aryl Acid Adenylation Domains.

Biochemistry - 4 Feb 2020

Ishikawa Fumihiro, Nohara Maya, Nakamura Shinya, Nakanishi Isao, Tanabe Genzoh

Abstract excerpt

Aryl acids are most commonly found in iron-scavenging siderophores but are not limited to them. The nonribosomal peptide synthetase (NRPS) codes of aryl acids remain poorly elucidated relative to those of amino acids. Here, we defined more precisely the role of active-site residues in aryl acid adenylation domains (A-domains) by gradually grafting the NRPS codes used for salicylic acid (Sal) into an archetypal...

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PMID: 31894971
DOI: 10.1021/acs.biochem.9b00748

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