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Article

Mutational analysis of an actin-binding site of cofilin and characterization of chimeric proteins between cofilin and destrin.

The Journal of biological chemistry - 15 Apr 1992

Moriyama K, Yonezawa N, Sakai H, Yahara I, Nishida E

Abstract excerpt

Cofilin and destrin are two related low molecular weight mammalian actin-binding proteins. Cofilin is an F-actin side-binding and pH-dependent actin-depolymerizing protein, and destrin is a pH-independent actin-depolymerizing protein. We have introduced a few point mutations within an actin-binding sequence of cofilin. Biochemical analyses of these mutant proteins have clearly shown that Lys112 and Lys114 of...

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PMID: 1313794

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