Article
Cofilin and gelsolin segment-1: molecular dynamics simulation and biochemical analysis predict a similar actin binding mode.
Journal of molecular biology - 9 Oct 1998
Wriggers W, Tang J X, Azuma T, Marks P W, Janmey P A
Abstract excerpt
An understanding of the actin-depolymerizing function attributed to members of the ADF/cofilin/destrin superfamily requires a structural model of these proteins in complex with actin. As a step toward defining actin-cofilin interactions, the complex of yeast cofilin with monomeric actin was predi...
Topics
- Actin Depolymerizing Factors
- Actins
- Binding, Competitive
- Computer Simulation
- Gelsolin
- Histidine
- Microfilament Proteins
- Microspheres
- Models, Molecular
- Mutation
- Peptide Fragments
- Protein Conformation
- Recombinant Proteins