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Article

Mapping the cofilin binding site on yeast G-actin by chemical cross-linking.

Journal of molecular biology - 21 Mar 2008

Grintsevich Elena E, Benchaar Sabrina A, Warshaviak Dora, Boontheung Pinmanee, Halgand Frédéric, Whitelegge Julian P, Faull Kym F, Loo Rachel R Ogorzalek, Sept David, Loo Joseph A, Reisler Emil

Abstract excerpt

Cofilin is a major cytoskeletal protein that binds to both monomeric actin (G-actin) and polymeric actin (F-actin) and is involved in microfilament dynamics. Although an atomic structure of the G-actin-cofilin complex does not exist, models of the complex have been built using molecular dynamics simulations, structural homology considerations, and synchrotron radiolytic footprinting data. The hydrophobic cleft...

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Identifiers

PMID: 18258262
DOI: 10.1016/j.jmb.2007.12.073
PMCID: PMC3052258

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Mapping the cofilin binding site on yeast G-actin by chemical cross-linking.PMID 18258262Read ↗

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