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Article

Molecular and biochemical characterization of the Skp2-Cks1 binding interface.

The Journal of biological chemistry - 3 Dec 2004

Wang Wei, Ungermannova Dana, Chen Lin, Liu Xuedong

Abstract excerpt

SCF(Skp2) is a multisubunit E3 ubiquitin ligase responsible for ubiquitination of cell cycle inhibitor p27. Ubiquitination of p27 requires an adapter protein, Cks1, to be in direct association with Skp2. The exact interface between Skp2 and Cks1 has not been elucidated. Here we have reported the definition of the critical functional interface between Skp2 and Cks1. We have identified eight amino acid residues in...

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Identifiers

PMID: 15452136
DOI: 10.1074/jbc.M405944200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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