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Article

Phosphorylation of Ser-3 of cofilin regulates its essential function on actin.

Genes to cells : devoted to molecular & cellular mechanisms - 1 Jan 1996

Moriyama K, Iida K, Yahara I

Abstract excerpt

BACKGROUND: Cofilin is a low-molecular weight actin-modulating protein, and is structurally and functionally conserved in eucaryotes from yeast to mammals. The functions of cofilin appear to be regulated by phosphorylation and dephosphorylation. RESULTS: A proteolytic study of phosphorylated porcine cofilin and expression of a mutated cofilin in cultured cells revealed that Ser-3 is the unique phosphorylation...

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Identifiers

PMID: 9078368
DOI: 10.1046/j.1365-2443.1996.05005.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Phosphorylation of Ser-3 of cofilin regulates its essential function on actin.PMID 9078368Read ↗

The actin-severing activity of cofilin is exerted by the interplay of three distinct sites on cofilin and essential for cell viability.Semantic proximity Read ↗

Distinct functional constraints driving conservation of the cofilin N-terminal regulatory tailSemantic proximity Read ↗

Cofilin promotes actin polymerization and defines the direction of cell motility.Semantic proximity Read ↗

Identification of yeast cofilin residues specific for actin monomer and PIP2 binding.Semantic proximity Read ↗

Structural Basis for Noncanonical Substrate Recognition of Cofilin/ADF Proteins by LIM Kinases.Semantic proximity Read ↗

Unbalancing the Phosphatidylinositol-4,5-bisphosphate–Cofilin Interaction Impairs Cell SteeringSemantic proximity Read ↗

Phosphorylation of the cytoskeletal protein CAP1 controls its association with cofilin and actin.Semantic proximity Read ↗

Two activities of cofilin, severing and accelerating directional depolymerization of actin filaments, are affected differentially by mutations around the actin-binding helix.Semantic proximity Read ↗

Cofilin nuclear-cytoplasmic shuttling affects cofilin-actin rod formation during stress.Semantic proximity Read ↗

Cofilin promotes rapid actin filament turnover in vivo.Semantic proximity Read ↗

Cofilin recruitment and function during actin-mediated endocytosis dictated by actin nucleotide state.Semantic proximity Read ↗

Cofilin cross-bridges adjacent actin protomers and replaces part of the longitudinal F-actin interface.Semantic proximity Read ↗

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