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Tumor-Enriched VCAN⁺ Macrophages Induce CD8⁺ T-Cell Exhaustion via STAT3–SPP1 Axis in Gastric Cancer

2026-05-14

Abstract excerpt

<title>Abstract</title> <p>Immune checkpoint blockade (ICB) achieves limited success in gastric cancer (GC), underscoring a need to resolve cellular mechanisms of resistance. Through single-cell transcriptomics, multi-omics profiling, and functional assays, we define a VCAN⁺ tumor-associated macrophage subset (VCAN⁺Mph) selectively enriched in GC tumors and linked to CD8⁺ T-cell dysfunction. VCAN⁺Mph resides at a...

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Literature Corpus work
a06e0170-00ac-5fcc-b86b-b739d3b26a64
DOI
10.21203/rs.3.rs-9519687/v1
Open publication

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Tumor-Enriched VCAN⁺ Macrophages Induce CD8⁺ T-Cell Exhaustion via STAT3–SPP1 Axis in Gastric CancerDOI 10.21203/rs.3.rs-9519687/v1
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