Article

Single-cell profiling of gastric cancer ascites reveals immunosuppressive remodeling and an epithelial-immune dual phenotype signature predictive for PD-1 immunotherapy responses

2025-10-27

Abstract excerpt

<title>Abstract</title> <p>Background Gastric cancer (GC) with peritoneal metastasis frequently leads to malignant ascites (MA), a highly immunosuppressive “liquid tumor microenvironment” associated with poor prognosis. Although immune checkpoint blockade (ICB) demonstrate efficacy in some GC patients, treatment response to gastric cancer-associated peritoneal metastasis (GCPM) remains heterogeneous. The immune m...

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Literature Corpus work: 8c7b4ad1-966a-5908-b41f-566633de89ee
DOI: 10.21203/rs.3.rs-7763100/v1

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