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scRNA-seq of gastric tumor shows complex intercellular interaction with an alternative T cell exhaustion trajectory

23 Aug 2022

Abstract excerpt

Abstract The tumor microenvironment (TME) in gastric cancer (GC) has been shown to be important for tumor control but the specific characteristics for GC are not fully appreciated. We generated an atlas of 166,533 cells from 10 GC patients with matched paratumor tissues and blood. Our results show tumor-associated stromal cells (TASCs) have upregulated activity of Wnt signaling and angiogenesis, and are...

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PMID: 35999201
DOI: 10.1038/s41467-022-32627-z

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