Single-cell profiling of gastric cancer ascites reveals an epithelial-immune dual phenotype signature predictive for anti-PD-1 immunotherapy responses.

doi:10.1186/s12916-026-05017-1

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Article

Single-cell profiling of gastric cancer ascites reveals an epithelial-immune dual phenotype signature predictive for anti-PD-1 immunotherapy responses.

BMC medicine - 29 Jun 2026

Xu Tianbing, Yang Muyang, Huang Jing, Lu Lisen, Deng Deqiang, Shi Xiujuan, Sun Yao, Lovell Jonathan F, Lin Zhenyu, Zheng Yongfa, Jin Honglin

Abstract excerpt

BACKGROUND: Gastric cancer (GC) with peritoneal metastasis frequently leads to malignant ascites (MA), a highly immunosuppressive "liquid tumor microenvironment" associated with poor prognosis. Although immune checkpoint blockade (ICB) demonstrate efficacy in some GC patients, treatment response to gastric cancer-associated peritoneal metastasis (GCPM) remains heterogeneous. The immune mechanisms driving this...

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Topics

Humans
Stomach Neoplasms
Ascites
Single-Cell Analysis
Immunotherapy
Programmed Cell Death 1 Receptor

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Female

Single-Cell Gene Expression Analysis

Male

Tumor Microenvironment

Phenotype

Immune Checkpoint Inhibitors

Middle Aged

Prognosis

Aged

Gene Expression Profiling

Source

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Identifiers

PMID: 42374437
DOI: 10.1186/s12916-026-05017-1
PMCID: PMC13579801

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