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Spatially resolved niche and tumor microenvironmental alterations in gastric cancer peritoneal metastases

2024-03-28

Abstract excerpt

Peritoneal metastases (PM) in gastric cancer (GC) portend a poor prognosis, yet our understanding of tumor microenvironmental (TME) characteristics associated with GCPM remain limited. Here, we analyzed intrinsic genomic alterations and transcriptomic programs predictive of GCPM in a prospective cohort of 248 patients, identifying CDH1 , PIGR , and ELF3 mutations as predictors. By inspecting the spatial dynamic...

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Literature Corpus work
395f4ae0-7172-5d42-8e78-cc2ac68e4541
DOI
10.1101/2024.03.21.585686
Open publication

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Spatially resolved niche and tumor microenvironmental alterations in gastric cancer peritoneal metastasesDOI 10.1101/2024.03.21.585686
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