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Single-cell and spatial transcriptomic profiling reveals impaired tertiary lymphoid structure maturation associated with T cell exhaustion in gastric cancer

2026-07-10

Abstract excerpt

<title>Abstract</title> <p>Background. Gastric cancer (GC) remains a leading cause of cancer-related mortality, and only a minority of patients derive durable benefit from immune checkpoint blockade (ICB). Tertiary lymphoid structures (TLS) are predictive of favorable ICB response in several solid tumors, yet their organization and functional context in GC remain incompletely defined. Methods. We integrated pub...

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Literature Corpus work
c5f5e0d0-065c-5a0f-b777-842254f48e28
DOI
10.21203/rs.3.rs-9900156/v1
Open publication

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Single-cell and spatial transcriptomic profiling reveals impaired tertiary lymphoid structure maturation associated with T cell exhaustion in gastric cancerDOI 10.21203/rs.3.rs-9900156/v1
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