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Article

Phenome-wide association study in adult coeliac disease: role of HLA subtype.

Alimentary pharmacology & therapeutics - 1 Feb 2021

Schneider Carolin V, Kleinjans Moritz, Fromme Malin, Schneider Kai Markus, Strnad Pavel

Abstract excerpt

BACKGROUND: Coeliac disease arises in genetically susceptible individuals, in particular in carriers of HLA-DQ2/DQ8 risk alleles and is associated with various comorbidities. Coeliac disease may confer an increased mortality, but the data are conflicting. AIMS: We aimed to characterize mortality and morbidity in patients with coeliac disease with a special focus on the role of the number of HLA risk alleles....

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PMID: 33280147
DOI: 10.1111/apt.16206

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