Article
APOBEC3B Does Not Promote Tumor Progression in Tp53 Hemizygous Mice.
Cancer reports (Hoboken, N.J.) - 1 Apr 2025
Horisawa Yoshihito, Matsumoto Tadahiko, Takeda June, Tashiro Yusuke, Nomura Ryosuke, Takeuchi Suguru, Kawai Yugo, Kazuma Yasuhiro, Konishi Yoshinobu, Yamazaki Hiroyuki, Matsui Hiroyuki, Shirakawa Kotaro, Takaori-Kondo Akifumi
Abstract excerpt
BACKGROUND: DNA cytosine deaminase APOBEC3B (A3B) is one of the endogenous sources of somatic mutations in many types of human cancers and is associated with tumor progression rather than tumorigenesis. However, it remains uncertain whether APOBEC3B-induced mutations accelerate tumor progression or not. In this paper, we established a mouse model with A3B overexpression and investigated whether the introduction...
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