Article
Genetic deletion and pharmacologic inhibition of FcER1 reduces renal injury in mouse models of diabetic nephropathy
2022-09-13
Abstract excerpt
FcER1 forms a high affinity multimeric cell-surface receptor for the Fc region of immunoglobulin E (IgE) and controls the activation of mast cells and basophils. Antigen binding and cross-linking of FcER1 associated IgE induces several downstream signaling pathways that result in diverse outcomes. Canonical signaling through IgE-FcER1 has been related to allergic responses, however, recent studies have identified...
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Identifiers and source
- Literature Corpus work
- a03ce554-b559-54bc-98fd-635f5077f76d
- DOI
- 10.1101/2022.09.10.507433