Article

Murine glomerular transcriptome links endothelial cell-specific molecule-1 deficiency with susceptibility to diabetic nephropathy

2017-05-27

Abstract excerpt

Diabetic nephropathy (DN) is the leading cause of kidney disease; however, there are no early biomarkers and no cure. Thus, there is a large unmet need to predict which individuals will develop nephropathy and to understand the molecular mechanisms which govern this susceptibility. We compared the glomerular transcriptome from mice with distinct susceptibilities to DN, and identified differential regulation of gen...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 93cbbf45-8936-54a1-afae-b035bcd6fa1f
DOI: 10.1101/143016

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Murine glomerular transcriptome links endothelial cell-specific molecule-1 deficiency with susceptibility to diabetic nephropathyDOI 10.1101/143016Read

Murine glomerular transcriptome links endothelial cell-specific molecule-1 deficiency with susceptibility to diabetic nephropathy.Semantic proximity Read

Endothelial Cell-Specific Molecule-1 Inhibits Albuminuria in Diabetic MiceSemantic proximity Read

Esm-1 mediates transcriptional polarization associated with diabetic kidney diseaseSemantic proximity Read

Gene expression programs of mouse endothelial cells in kidney development and disease.Semantic proximity Read

Glomerular cell atlas of multi-disease model revealed the characteristic changes of glomerular cell subtypes in diseases.Semantic proximity Read

Gene expression profiles of glomerular endothelial cells support their role in the glomerulopathy of diabetic miceSemantic proximity Read

Single-cell transcriptomics reveals a mechanosensitive injury signaling pathway in early diabetic nephropathySemantic proximity Read

A Single-Cell Transcriptome Atlas of the Mouse GlomerulusSemantic proximity Read

Inflammatory molecules in the glomerular endothelium in mild IgA-Nephropathy identified by single-cell and spatial transcriptomeSemantic proximity Read

Renal Endothelial Single-Cell Transcriptomics Reveals Spatiotemporal Regulation and Divergent Roles of Differential Gene Transcription and Alternative Splicing in Murine Diabetic NephropathySemantic proximity Read

Inflammation and Immunity Pathways Regulate Genetic Susceptibility to Diabetic Nephropathy.Semantic proximity Read