Article
Mouse model recapitulating human Fcγ receptor structural and functional diversity.
Proceedings of the National Academy of Sciences of the United States of America - 17 Apr 2012
Smith Patrick, DiLillo David J, Bournazos Stylianos, Li Fubin, Ravetch Jeffrey V
Abstract excerpt
The in vivo biological activities of IgG antibodies result from their bifunctional nature, in which antigen recognition by the Fab is coupled to the effector and immunomodulatory diversity found in the Fc domain. This diversity, resulting from both amino acid and glycan heterogeneity, is translated into cellular responses through Fcγ receptors (FcγRs), a structurally and functionally diverse family of cell...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.