Article
Recent Insights into Experimental Mouse Models of Diabetic Nephropathy
21 Jun 2006
Abstract excerpt
BACKGROUND/AIMS: Mouse models are an essential experimental tool for investigating the role of molecular mechanisms and genetic susceptibility in the development of diabetic nephropathy. METHODS: The most widely used inbred strain, the C57BL/6 mouse, is commonly used in streptozotocin-induced models of type 1 diabetes and is particularly susceptible to obesity-induced type 2 diabetes. However, use of this strain...
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