Article
Haploinsufficiency of protamine-1 or -2 causes infertility in mice.
Nature genetics - 1 May 2001
Cho C, Willis W D, Goulding E H, Jung-Ha H, Choi Y C, Hecht N B, Eddy E M
Abstract excerpt
Protamines are the major DNA-binding proteins in the nucleus of sperm in most vertebrates and package the DNA in a volume less than 5% of a somatic cell nucleus. Many mammals have one protamine, but a few species, including humans and mice, have two. Here we use gene targeting to determine if the...
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