Article
Haploinsufficiency of protamine-1 or -2 causes infertility in mice.
Nature genetics - 1 May 2001
Cho C, Willis W D, Goulding E H, Jung-Ha H, Choi Y C, Hecht N B, Eddy E M
Abstract excerpt
Protamines are the major DNA-binding proteins in the nucleus of sperm in most vertebrates and package the DNA in a volume less than 5% of a somatic cell nucleus. Many mammals have one protamine, but a few species, including humans and mice, have two. Here we use gene targeting to determine if the second protamine provides redundancy to an essential process, or if both protamines are necessary. We disrupted the...
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