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Article

Sperm chromatin structure and reproductive fitness are altered by substitution of a single amino acid in mouse protamine 1

17 Jul 2023

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Share to Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
Share to Reproductive Biology and Fertility
Share to Sperm and Testicular Function

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PMID: 37460896
DOI: 10.1038/s41594-023-01033-4

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Sperm chromatin structure and reproductive fitness are altered by substitution of a single amino acid in mouse protamine 1PMID 37460896Read ↗

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Loss of <i>Prm1</i> leads to defective chromatin protamination, impaired PRM2 processing, reduced sperm motility and subfertility in male miceSemantic proximity Read ↗

Viable offspring obtained from Prm1-deficient sperm in miceSemantic proximity Read ↗

Insights into the sperm chromatin and implications for male infertility from a protein perspectiveSemantic proximity Read ↗

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