Article

Protamine sequence determines species-specific nuclear shape and histone retention

2025-03-22

Abstract excerpt

Nuclear shape observed after the forced expression of mouse or human Protamine 1 (PRM1) in fibroblasts led us to propose the hypothesis that PRM1 sequence plays an important role in imposing the overall shape of the protaminized nucleus. Comparison of mouse and human PRM1 sequence pointed to cysteines 15 and 29 as potential critical residues in the mouse PRM1 sequence inducing the characteristic mouse “hooked” nuc...

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Literature Corpus work: 04e0b55c-e4bf-5942-85eb-d17f41bd8362
DOI: 10.1101/2025.03.20.644273

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