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Loss of <i>Prm1</i> leads to defective chromatin protamination, impaired PRM2 processing, reduced sperm motility and subfertility in male mice

2021-10-29

Abstract excerpt

One of the key events during spermiogenesis is the hypercondensation of chromatin by substitution of the majority of histones by protamines. In humans and mice, protamine 1 ( PRM1/Prm1 ) and protamine 2 ( PRM2/Prm2 ), are expressed in a species-specific ratio. Using CRISPR-Cas9-mediated gene editing we generated Prm1 -deficient mice and demonstrate, that Prm1+/- mice are subfertile while Prm1-/- are infertile...

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Literature Corpus work
5a08592c-1674-51b2-ad4d-a6880d280f0a
DOI
10.1101/2021.10.29.466452
Open publication

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Loss of <i>Prm1</i> leads to defective chromatin protamination, impaired PRM2 processing, reduced sperm motility and subfertility in male miceDOI 10.1101/2021.10.29.466452
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