Article

Aging-associated alterations in the mammary gland revealed by single-cell RNA sequencing

2019-09-18

Abstract excerpt

Aging of the mammary gland is closely associated with increased susceptibility to diseases such as cancer, but there have been limited systematic studies of aging-induced alterations within this organ. We performed high-throughput single-cell RNA-sequencing (scRNA-seq) profiling of mammary tissues from young and old nulliparous mice, including both epithelial and stromal cell types. Our analysis identified altered...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a01c4f43-41eb-5e63-80d9-6459cbca7241
DOI: 10.1101/773408

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Aging-associated alterations in the mammary gland revealed by single-cell RNA sequencingDOI 10.1101/773408Read

Comprehensive single cell aging atlas of mammary tissues reveals shared epigenomic and transcriptomic signatures of aging and cancerSemantic proximity Read

Differentiation dynamics of mammary epithelial cells revealed by single-cell RNA sequencingSemantic proximity Read

Mammary cell gene expression atlas links epithelial cell remodeling events to breast carcinogenesisSemantic proximity Read

An atlas of the aging lung mapped by single cell transcriptomics and deep tissue proteomicsSemantic proximity Read

Comprehensive single-cell aging atlas of healthy mammary tissues reveals shared epigenomic and transcriptomic signatures of aging and cancerSemantic proximity Read

Single-cell RNA-Seq reveals cell heterogeneity and hierarchy within mouse mammary epitheliaSemantic proximity Read

Single-cell transcriptomics reveals involution mimicry during the specification of the basal breast cancer subtypeSemantic proximity Read

A single-cell atlas of the aging mouse ovarySemantic proximity Read

An atlas of the aging lung mapped by single cell transcriptomics and deep tissue proteomicsSemantic proximity Read

Single-Cell Transcriptomes Distinguish Stem Cell State Changes and Lineage Specification Programs in Early Mammary Gland DevelopmentSemantic proximity Read

Single Cell RNA Sequencing of Human Milk-Derived Cells Reveals Sub-Populations of Mammary Epithelial Cells with Molecular Signatures of Progenitor and Mature States: a Novel, Non-invasive Framework for Investigating Human Lactation PhysiologySemantic proximity Read

Single-Cell Transcriptome Analyses Reveal the Cell Diversity and Developmental Features of Human Gastric and Metaplastic MucosaSemantic proximity Read