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Article

A single-cell atlas of the aging mouse ovary

10 Jan 2024

Abstract excerpt

Ovarian aging leads to diminished fertility, dysregulated endocrine signaling and increased chronic disease burden. These effects begin to emerge long before follicular exhaustion. Female humans experience a sharp decline in fertility around 35 years of age, which corresponds to declines in oocyte quality. Despite a growing body of work, the field lacks a comprehensive cellular map of the transcriptomic changes...

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PMID: 38200272
DOI: 10.1038/s43587-023-00552-5

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