Article
Borderline rpoB mutations transmit at the same rate as common rpoB mutations in a tuberculosis cohort in Bangladesh.
Microbial genomics - 1 Sept 2023
Lempens Pauline, Van Deun Armand, Aung Kya J M, Hossain Mohammad A, Behruznia Mahboobeh, Decroo Tom, Rigouts Leen, de Jong Bouke C, Meehan Conor J
Abstract excerpt
The spread of multidrug-resistant tuberculosis (MDR-TB) is a growing problem in many countries worldwide. Resistance to one of the primary first-line drugs, rifampicin, is caused by mutations in the Mycobacterium tuberculosis rpoB gene. So-called borderline rpoB mutations confer low-level resistance, in contrast to more common rpoB mutations which confer high-level resistance. While some borderline mutations show...
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