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Functional insights from a surface antigen mRNA-bound proteome

30 Mar 2021

Abstract excerpt

Trypanosoma brucei is the causative agent of human sleeping sickness. The parasites’ variant surface glycoprotein (VSG) enables them to evade adaptive immunity via antigenic variation. VSG comprises 10% of total cell protein and the high stability of VSG mRNA is essential for trypanosome survival. To determine how VSG mRNA stability is maintained, we used mRNA affinity purification to identify all its associated...

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PMID: 33783358
DOI: 10.7554/elife.68136

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