Article
Triple-negative breast tumors are dependent on mutant p53 for growth and survival.
Proceedings of the National Academy of Sciences of the United States of America - 22 Aug 2023
Dibra Denada, Moyer Sydney M, El-Naggar Adel K, Qi Yuan, Su Xiaoping, Lozano Guillermina
Abstract excerpt
The TP53 tumor suppressor gene is mutated early in the majority of patients with triple-negative breast cancer (TNBC). The most frequent TP53 alterations are missense mutations that contribute to tumor aggressiveness. We developed an autochthonous somatic K14-Cre driven TNBC mouse model with p53R172H and p53R245W mutations in which mutant p53 can be toggled on and off genetically while leaving the tumor...
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