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Article

Gain of function in the mouse model of a recurrent mutation p53N236S promotes the formation of double minute chromosomes and the oncogenic potential of p19ARF.

Molecular carcinogenesis - 1 Feb 2018

Zhao Lanjun, Wang Boyuan, Zhao Xilong, Wu Xiaoming, Zhang Qiushi, Wei Chuanyu, Shi Minling, Li Yunlong, Tang Wenru, Zhang Jihong, Yang Julun, Singh Sanjay K, Jia Shuting, Luo Ying

Abstract excerpt

The mutation p53N236S (p53S) has been identified as one of the recurrent mutations in human cancers by TCGA database. Our in vitro data revealed the oncogenic gain of function of p53S. To understand the function of p53S in vivo, we generated the p53S knock-in mouse. The p53S/S mice manifested highly invasive lymphomas and metastatic sarcomas with dramatically increased double minute chromosomes. The survival...

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PMID: 28949402
DOI: 10.1002/mc.22737

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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