Article
tp53 mutant zebrafish develop malignant peripheral nerve sheath tumors.
Proceedings of the National Academy of Sciences of the United States of America - 11 Jan 2005
Berghmans Stéphane, Murphey Ryan D, Wienholds Erno, Neuberg Donna, Kutok Jeffery L, Fletcher Christopher D M, Morris John P, Liu Ting Xi, Schulte-Merker Stefan, Kanki John P, Plasterk Ronald, Zon Leonard I, Look A Thomas
Abstract excerpt
TP53 is the most frequently mutated tumor suppressor gene in human cancer, with nearly 50% of all tumors exhibiting a loss-of-function mutation. To further elucidate the genetic pathways involving TP53 and cancer, we have exploited the zebrafish, a powerful vertebrate model system that is amenable to whole-genome forward-genetic analysis and synthetic-lethal screens. Zebrafish lines harboring missense mutations...
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