Article

The CdGAP C-terminal pro-invasive domain drives breast cancer metastasis and activates WNT signaling

2026-06-26

Abstract excerpt

<title>Abstract</title> <p>Triple-negative breast cancer (TNBC) is an aggressive disease with limited therapeutic options and a high propensity for metastasis. Cdc42 GTPase-activating protein (CdGAP/ARHGAP31) is highly expressed in TNBC, yet the molecular determinants underlying its pro-metastatic activity remain unclear. Here, we identify a pro-invasive domain (PID) within the C-terminus of CdGAP required for br...

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Literature Corpus work: 9f910ecb-18c6-5b98-b8b4-d8c776d58df2
DOI: 10.21203/rs.3.rs-9917734/v1

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