Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Comprehensive molecular characterization of Rho GTPases and their regulators across human cancers.

International journal of cancer - 1 Dec 2025

Luo Shangyi, Qiao Shupei, Liu Li, Jia Ying, Zhang Yajing, Zhang Xue

Abstract excerpt

Although defects in Rho GTPases have been implicated in cancer, a systematic assessment of the alterations in Rho GTPases and their regulators that facilitate conformational cycling between the active GTP-bound and inactive GDP-bound Rho GTPases is lacking across human cancers. Here, we depicted a comprehensive molecular characterization of 169 genes encoding Rho GTPases and their regulators, utilizing...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinoma, Hepatocellular
Share to Gene Expression Profiling

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Neoplastic

Share to Liver Neoplasms

Share to MicroRNAs

Share to Mutation

Share to Neoplasms

Share to rho GTP-Binding Proteins

Source

Identifiers

PMID: 40778428
DOI: 10.1002/ijc.70077

Genes

SYDE2
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 18 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Comprehensive molecular characterization of Rho GTPases and their regulators across human cancers.PMID 40778428Read ↗

Rho GTPases in human cancer: an unresolved link to upstream and downstream transcriptional regulationSemantic proximity Read ↗

Deregulation of Rho GTPases in cancer.Semantic proximity Read ↗

Variegated RHOA mutations in human cancers.Semantic proximity Read ↗

Rho GTPases modulate malignant transformation of tumor cells.Semantic proximity Read ↗

Fixing the GAP: The role of RhoGAPs in cancerSemantic proximity Read ↗

RHO GTPases in cancer: known facts, open questions, and therapeutic challenges.Semantic proximity Read ↗

Rho GTPase activating proteins in cancer phenotypes.Semantic proximity Read ↗

Rho GTPases, their post-translational modifications, disease-associated mutations and pharmacological inhibitors.Semantic proximity Read ↗

Targeting Rho GTPase Signaling Networks in CancerSemantic proximity Read ↗

Regulation of Rho GTPases by RhoGDIs in Human CancersSemantic proximity Read ↗

Rho GTPases signaling mediates aggressiveness and differentiation in neuroblastoma tumorsSemantic proximity Read ↗

Integrated Pan-Cancer Profiling of RAC1: Prognostic, Immunomodulatory, and Therapeutic Resistance InsightsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.