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Article

Structure-guided in vitro evolution of nanobodies targeting new viral variants.

PLoS pathogens - 1 Sept 2024

Ye Gang, Bu Fan, Pan Ruangang, Mendoza Alise, Yang Ge, Spiller Benjamin, Wadzinski Brian E, Du Lanying, Perlman Stanley, Liu Bin, Li Fang

Abstract excerpt

A major challenge in antiviral antibody therapy is keeping up with the rapid evolution of viruses. Our research shows that nanobodies - single-domain antibodies derived from camelids - can be rapidly re-engineered to combat new viral strains through structure-guided in vitro evolution. Specifically, for viral mutations occurring at nanobody-binding sites, we introduce randomized amino acid sequences into nanobody...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39325826
DOI: 10.1371/journal.ppat.1012600
PMCID: PMC11460708

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